SML2765
Glutor
≥98% (HPLC), glucose uptake inhibitor, powder
Synonym(s):
(S)-6-Methyl-5-(4-morpholinobenzyl)-4-oxo-2-phenyl-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-6-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C31H32N6O3
Molecular Weight:
536.62
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Glutor, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Glutor is a potent inhibitor of glucose uptake that targets glucose transporters GLUT1, -2, and -3. Inhibition of glucose uptake by glutor leads to upregulation of GLUT3 and GLUT1 expression. Glutor potently and selectively suppresses growth of a variety of cancer cell lines. Glutor and glutaminase inhibitor CB-839 synergistically inhibit tumor cell growth.
potent inhibitor of glucose uptake that targets glucose transporters GLUT-1, -2, and -3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Elena S Reckzeh et al.
Cell chemical biology, 26(9), 1214-1228 (2019-07-16)
Cancer cells sustain growth by altering their metabolism to accelerated aerobic glycolysis accompanied by increased glucose demand and employ glutamine as additional nutrient source. This metabolic adaptation induces upregulation of glucose transporters GLUT-1 and -3, and simultaneous targeting of both
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