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SML2771

Amonafide

≥98% (HPLC)

Synonym(s):

5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, AS1413, FA 142, NSC 308847, Nafidimide

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About This Item

Empirical Formula (Hill Notation):
C16H17N3O2
CAS Number:
69408-81-7
Molecular Weight:
283.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00866438
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[n]1([c](c2c3c([c]1=O)cccc3cc(c2)N)=O)CCN(C)C

InChI

1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3

InChI key

UPALIKSFLSVKIS-UHFFFAOYSA-N

Biochem/physiol Actions

Amonafide, a naphthalimides DNA intercalator, is a potent topoisomerase II inhibitor that inhibits tumor proliferation and progression. It appears that Amonafide inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.
DNA intercalator and potent topoisomerase II inhibitor

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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