SML2781
NV-5440
≥98% (HPLC), class I glucose transporters (GLUT1) inhibitor, powder
Synonym(s):
2-[4-[5-[[4-(2-Cyanophenyl)-1-piperazinyl]methyl]-2,4-dimethylbenzoyl]-1-piperazinyl]-benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C31H36N6O3S
CAS Number:
Molecular Weight:
572.72
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
NV-5440, ≥98% (HPLC)
InChI key
BREWSTIKWAQLCH-UHFFFAOYSA-N
SMILES string
CC1=C(C=C(C(C)=C1)CN2CCN(CC2)C3=C(C=CC=C3)C#N)C(N4CCN(CC4)C5=CC=CC=C5S(N)(=O)=O)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
NV-5440 is a cell penetrant, potent and selective class I glucose transporters (GLUT1) inhibitor that selectively inhibits mTORC1 pathway in vivo. NV-5440 acts as a potent inhibitor of glycolysis in cells.
cell penetrant, potent and selective GLUT1 inhibitor that selectively inhibits mTORC1 pathway in vivo
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Seong A Kang et al.
Cell chemical biology, 26(9), 1203-1213 (2019-06-25)
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolic processes. Dysregulation of this kinase complex can result in a variety of human diseases. Rapamycin and its analogs target mTORC1 directly; however, chronic treatment in certain cell
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