SML2787
DJ001 (E/Z)
≥98% (HPLC)
Synonym(s):
Compound 5483071, (2E/Z)-3-[(3-Nitrophenyl)amino]-1-phenyl-2-propen-1-one, (E/Z)-3-((3-nitrophenyl)amino)-1-phenylprop-2-en-1-one, (E/Z)-3-(3-Nitrophenylamino)-1-phenylprop-2-en-1-one, (E/Z)-DJ001, Compound 3071
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About This Item
Empirical Formula (Hill Notation):
C15H12N2O3
CAS Number:
Molecular Weight:
268.27
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=CC=C1)/C=C\NC2=CC=CC([N+]([O-])=O)=C2
InChI
1S/C15H12N2O3/c18-15(12-5-2-1-3-6-12)9-10-16-13-7-4-8-14(11-13)17(19)20/h1-11,16H/b10-9-
InChI key
OVTJWWUGQKIRCL-KTKRTIGZSA-N
Biochem/physiol Actions
DJ001 is a selective, allosteric and non-competitive receptor protein tyrosine phosphatase-sigma (PTPσ) inhibitor (IC50 = 1.43 μM; >10 μM/20 other phosphatases) that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion (0.1-1 μg/mL or 0.373-3.73 μM; murine CD34- KSL cells) and suppresses radiation-induced BM HSC apoptosis (1-5 μg/mL; murine KSL & human CD34+ cells) via RhoGTPase/RAC1 activation and BCL-XL induction. DJ001 accelerates hematologic recovery and improves survival of irradiated mice in vivo (5 mg/kg/d s.c.). The (Z)- & (E)-isomers exist in equilibrium in polar solvents with (Z) showing enhanced binding-affinity to PTPσ catalytic & allosteric sites.
Selective, allosteric receptor protein tyrosine phosphatase-sigma (PTPσ) inhibitor that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion in vitro & in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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