SML2789
tBPC
≥98% (HPLC)
Synonym(s):
2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol
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About This Item
Empirical Formula (Hill Notation):
C16H24O2
CAS Number:
Molecular Weight:
248.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O(C2C(CCCC2)O)c1ccc(cc1)C(C)(C)C
InChI
1S/C16H24O2/c1-16(2,3)12-8-10-13(11-9-12)18-15-7-5-4-6-14(15)17/h8-11,14-15,17H,4-7H2,1-3H3
InChI key
FTIXUILRMBSXNS-UHFFFAOYSA-N
Biochem/physiol Actions
Postitive allosteric modulator of NPY Y4 receptor
tBPC is a postitive allosteric modulator of the neuropeptide Y (NPY) Y4 receptor, which is predominantly expressed in the gastrointestinal tract and activated most strongly by pancreatic polypeptide (PP). tBPC was shown to potentiate Y4R activity in G-Protein signaling and arrestin3 recruitment and to potentiate the native PP response. tBPC was selective for Y4R over other Neuropeptide Y receptors and showed no effect on the efficacy (Emax) or potency (EC50) of the NPY signal response at the Y1, Y2, or Y5 receptors at 30 μM.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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