SML2810
Prostetin Trifluoroacetic acid salt
≥98% (HPLC), MAP4K inhibitor, powder
Synonym(s):
2-(4-(4-(3-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)piperazin-1-yl)ethan-1-ol Trifluoroacetic acid salt, 2-(4-(4-(3-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)piperazin-1-yl)ethanol Trifluoroacetic acid salt, 4-[[4-[3-(3-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-1-piperazineethanol Trifluoroacetic acid salt
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About This Item
Empirical Formula (Hill Notation):
C26H27ClN4O · xC2HF3O2
Molecular Weight:
446.97 (free base basis)
UNSPSC Code:
12352106
NACRES:
NA.77
Product Name
Prostetin Trifluoroacetic acid salt, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Prostetin is an orally available, blood-brain barrier-penetrant, potent and metabolically stable inhibitor of the mitogen-activated protein kinase kinase kinase kinase (MAP4K, or HGK) that exhibits neuroprotective and anti-inflammatory properties. Prostetin is more potent than URMC-099 in motor neuron survival assay. Prostetin rescues CPA-induced neurodegeneration in motor neurons.
orally available, blood-brain barrier-penetrant, potent and metabolically stable inhibitor of MAP4K (HGK) that exhibits neuroprotective properties
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Pieter H Bos et al.
Cell chemical biology, 26(12), 1703-1715 (2019-11-05)
Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for patients with these diseases. Using an in vitro screening platform to identify compounds that protect human motor neurons from ER
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2810-25MG | 04061841728252 |
| SML2810-5MG | 04061841728269 |