SML2812
AN1
≥98% (HPLC)
Synonym(s):
5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1
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About This Item
Empirical Formula (Hill Notation):
C15H9Br2NO3
CAS Number:
Molecular Weight:
411.04
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
AN1, ≥98% (HPLC)
SMILES string
Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O
InChI key
GPKLWRHHVIBYEO-UHFFFAOYSA-N
InChI
1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.
brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Zhaoyang Li et al.
Nature, 575(7781), 203-209 (2019-11-02)
Accumulation of mutant proteins is a major cause of many diseases (collectively called proteopathies), and lowering the level of these proteins can be useful for treatment of these diseases. We hypothesized that compounds that interact with both the autophagosome protein
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