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Merck
CN

SML2816

Sigma-Aldrich

BS46 bromide

≥98% (HPLC)

Synonym(s):

(1R,2R,4S,5S,7S)-7-[({4-Fluoro-2-(thiophen-2-yl)phenyl}carbamoyl)oxy]-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide

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About This Item

Empirical Formula (Hill Notation):
C20H22BrFN2O3S
Molecular Weight:
469.37
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

FC1=CC=C(NC(O[C@@H]2C[C@H]([C@@H]3[C@H]4O3)[N+](C)(C)[C@H]4C2)=O)C(C5=CC=CS5)=C1.[Br-]

Biochem/physiol Actions

BS46 is a highly potent and selective muscarinic acetylcholine receptor antagonist that exhibits 33-fold preference for M3R (M3 muscarinic acetylcholine receptor) over M2R. It fully inhibits carbachol-induced inositol monophosphate accumulation as well as ?-arrestin recruitment at M3Rs. BS46 exhibits 100,000-fold selectivity for muscarinic receptors against 21 aminergic and peptidergic GPCRs.
highly potent and selective M3 muscarinic acetylcholine receptor (M3R) antagonist that exhibits 33-fold preference for M3R over M2R

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000097945
0000097946
0000094234

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Hongtao Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(47), 12046-12050 (2018-11-09)
Drugs that treat chronic obstructive pulmonary disease by antagonizing the M3 muscarinic acetylcholine receptor (M3R) have had a significant effect on health, but can suffer from their lack of selectivity against the M2R subtype, which modulates heart rate. Beginning with

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