SML2817
BAY-1797
≥98% (HPLC), P2X4 antagonist, powder
Synonym(s):
N-(4-(3-Chlorophenoxy)-3-sulfamoylphenyl)-2-phenylacetamide, N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
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About This Item
Empirical Formula (Hill Notation):
C20H17ClN2O4S
CAS Number:
Molecular Weight:
416.88
UNSPSC Code:
51111800
NACRES:
NA.77
Product Name
BAY-1797, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC=CC(OC2=C(C=C(NC(CC3=CC=CC=C3)=O)C=C2)S(=O)(N)=O)=C1
InChI key
CSJYMAFXYMYNCK-UHFFFAOYSA-N
Biochem/physiol Actions
BAY-1797 orally available, potent and selective P2X4 antagonist that is suitable for in vivo studies in rodents. BAY-1797 exhibits potent anti-inflammatory and anti-nociceptive effects in mouse CFA inflammatory pain model.
potent and selective P2X4 antagonist
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Stefan Werner et al.
Journal of medicinal chemistry, 62(24), 11194-11217 (2019-11-21)
The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety of cell types, especially those involved in inflammatory and immune processes. High-throughput screening led to a new class of P2X4 inhibitors with substantial CYP 3A4 induction
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2817-25MG | 04061842610792 |
| SML2817-5MG | 04061842610808 |