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Merck
CN

SML2821

DiFMUP

≥98% (HPLC), Fluorogenic alkaline phosphatase substrate, powder

Synonym(s):

6,8-Difluoro-4-methylumbelliferyl phosphate, 6,8-Difluoro-4-methyl-7-(phosphonooxy)-2H-1-benzopyran-2-one, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-7-hydroxy-4-methylcoumarin phosphate

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About This Item

Empirical Formula (Hill Notation):
C10H7F2O6P
CAS Number:
214491-43-7
Molecular Weight:
292.13
MDL number:
MFCD01863005
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

DiFMUP, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

CC1=CC(=O)Oc2c(F)c(OP(O)(O)=O)c(F)cc12

InChI

1S/C10H7F2O6P/c1-4-2-7(13)17-9-5(4)3-6(11)10(8(9)12)18-19(14,15)16/h2-3H,1H3,(H2,14,15,16)

InChI key

DZANYXOTJVLAEE-UHFFFAOYSA-N

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Biochem/physiol Actions

DiFMUP (6,8-difluoro-4-methylumbelliferyl phosphate), a fluorinated analog of MUP, is a fluorescent synthetic substrate for continuous assessment of phosphatase activity. DiFMUP excitation/emission maxima are 358/450 nm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000440390
0000440389
0000440389
0000440390
0000410114

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Brandon S McCullough et al.
Biochemistry, 57(18), 2584-2589 (2018-04-10)
Although the importance of protein histidine phosphorylation in mammals has been a subject of increasing interest, few chemical probes are available for monitoring and manipulating PHP activity. Here, we present an optimized and validated protocol for assaying the activity of
Stefan Welte et al.
Analytical biochemistry, 338(1), 32-38 (2005-02-15)
The fluorogenic substrate 6,8-difluoro-4-methylumbiliferyl phosphate (DIFMUP) has been widely used for the detection of serine and threonine phosphatase activities. Here we describe the use of this substrate for the characterization of protein tyrosine phosphatases (PTPs) and for the screening for
John S Lazo et al.
The Journal of pharmacology and experimental therapeutics, 371(3), 652-662 (2019-10-12)
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant processes. 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione (JMS-053) is a novel, potent, and selective PTP4A inhibitor

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