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Merck
CN

SML2843

NS3623

≥98% (HPLC)

Synonym(s):

1-(3-Trifluoromethylphenyl)-3-[2-(1H-tetrazol-5-yl)-4-bromophenyl]urea, N-[4-Bromo-2-(2H-tetrazol-5-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea, NS 3623

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About This Item

Empirical Formula (Hill Notation):
C15H10BrF3N6O
CAS Number:
343630-41-1
Molecular Weight:
427.18
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD22683830

Key Documents

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SMILES string

FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(cc(cc2)Br)c3[nH]nnn3

InChI

1S/C15H10BrF3N6O/c16-9-4-5-12(11(7-9)13-22-24-25-23-13)21-14(26)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H2,20,21,26)(H,22,23,24,25)

InChI key

JXPULDIATMTIIN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

NS3623 is a potent and selective activator of KV11.1 (hERG) and KV4.3 channels. It activates the IKr and Ito currents and exhibits antiarrhythmic activity. NS3623 may also act as a partial blocker of KV11.1 channels.
potent and selective activator of KV11.1 (hERG) and KV4.3 channels; antiarrhythmic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000193547
0000193547
0000104799
0000104798
0000101517

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Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]
Hansen RS, Diness TG, Christ T, Wettwer E, Ravens U, Olesen SP, Grunnet M
Molecular Pharmacology, 70, 1319-1329 (2006)
Jacqueline A Treat et al.
Biochemical pharmacology, 169, 113608-113608 (2019-08-30)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are used for many applications including safety pharmacology. However, a deficiency or complete absence of several K+ currents suggests repolarization reserve is low in hiPSC-CMs. We determined whether a dual Ito and IKr
Sergio Lainez et al.
Biochemical pharmacology, 150, 120-130 (2018-01-30)
Transient outward potassium current (Ito) contributes to early repolarization of many mammalian cardiac action potentials, including human, whilst the rapid delayed rectifier K+ current (IKr) contributes to later repolarization. Fast Ito channels can be produced from the Shal family KCNDE

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