SML2854
Polmacoxib
≥98% (HPLC)
Synonym(s):
4-[3-(3-fluorophenyl)-4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl]-benzenesulfonamide, CG100649
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About This Item
Empirical Formula (Hill Notation):
C18H16FNO4S
CAS Number:
Molecular Weight:
361.39
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
InChI
1S/C18H16FNO4S/c1-18(2)17(21)15(12-4-3-5-13(19)10-12)16(24-18)11-6-8-14(9-7-11)25(20,22)23/h3-10H,1-2H3,(H2,20,22,23)
InChI key
IJWPAFMIFNSIGD-UHFFFAOYSA-N
SMILES string
NS(C1=CC=C(C=C1)C(OC2(C)C)=C(C2=O)C3=CC=CC(F)=C3)(=O)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrases CAI and CAII
Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) that acts as an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrases CAI and CAII. It has also been found to inhibit colorectal adenoma and tumor growth in mouse models.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Hyun Tae Kim et al.
Biochemical and biophysical research communications, 478(1), 1-6 (2016-08-01)
Polmacoxib is not only a selective COX-2 inhibitor but also a potent inhibitor of carbonic anhydrases (CAs). Both CA I and CA II are highly expressed in the GI tract and kidneys, organs that are also thought to be the
Myungchul Lee et al.
Clinics in orthopedic surgery, 9(4), 439-457 (2017-12-05)
The aim of this study was to evaluate the safety and analgesic efficacy of polmacoxib 2 mg versus placebo in a superiority comparison or versus celecoxib 200 mg in a noninferiority comparison in patients with osteoarthritis (OA). This study was
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