SML2861
FIT-039
≥98% (HPLC)
别名:
FIT 039, FIT039, N-(5-Fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide, N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide
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关于此项目
经验公式（希尔记法）:
C17H18FN3S
化学文摘社编号:
分子量:
315.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Fc1cc(c(cc1)N3CCCCC3)NC(=S)c2ccncc2
InChI key
VRKZHYSJZOUICG-UHFFFAOYSA-N
Biochem/physiol Actions
FIT-039 is a potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor that binds to the ATP -binding pocket of CDK9 and inhibits the kinase activity of P-TEFb complex. FIT-039 inhibits replication of herpes simplex virus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured cells. FIT-039 ointment inhibits formation of skin legion in a mice HSV-1 infection model.
potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor; antiviral agent
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable