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Merck
CN

SML2885

Sigma-Aldrich

Ac-SDKP trifluoroacetate

≥95% (HPLC)

Synonym(s):

Ac-SDKP-OH trifluoroacetate, Ac-Ser-Asp-Lys-Pro-OH trifluoroacetate, AcSDKP trifluoroacetate, Goralatide trifluoroacetate, N-acetyl-L-seryl-L-a-aspartyl-L-lysyl-L-proline trifluoroacetate, N-acetyl-Ser-Asp-Lys-Pro-OH trifluoroacetate, Thymosin ß4 (1-4) trifluoroacetate, Tß4 (1-4) trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C20H33N5O9 · xC2HF3O2
CAS Number:
1796568-94-9
Molecular Weight:
487.50 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized powder

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

Originally characterized as a "spleen colony-forming units (CFU-S) inhibitor" for its activity against hematopoietic pluripotent stem cell proliferation, Ac-SDKP (Goralatide) is an immunomodulatory and pro-angiogenic tetrapeptide derived from the N-terminal end of thymosin β4 (Tβ4 aa 1-4) via sequential enzymatic actions of meprin-α and prolyl-oligopeptidase (POP), while angiotensin converting enzyme (ACE) mediates Ac-SDKP degradation. In animal heart, kidney and brain injury studies, Ac-SDKP ameliorates end-organ damage by promoting angiogenesis, as well as by reducing inflammation and fibrosis.
Thymosin β4 (Tβ4)-derived immunomodulatory and pro-angiogenic peptide with in vivo anti-inflammatory and anti-fibrotic efficacy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000103759
0000103671
0000101381

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M Lenfant et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(3), 779-782 (1989-02-01)
We report here a five-step purification procedure that led to the isolation from fetal calf bone marrow extract of a tetrapeptide, Ac-Ser-Asp-Lys-Pro (Mr 487), exerting a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells [defined here as
Lijuan Zhang et al.
Toxicology and applied pharmacology, 350, 1-10 (2018-04-24)
Damage to alveolar epithelial cells (AECs) caused by long-term inhalation of large amounts of silica dust plays a significant role in the pathology of silicosis. The present study was undertaken to investigate the regulatory mechanism(s) involved in type II AEC
Umesh C Sharma et al.
Circulation. Heart failure, 11(8), e004867-e004867 (2018-10-26)
Advances in radiotherapy for thoracic cancers have resulted in improvement of survival. However, radiation exposure to the heart can induce cardiotoxicity. No therapy is currently available to inhibit these untoward effects. We examined whether a small tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), can
Nitin Kumar et al.
American journal of physiology. Renal physiology, 310(10), F1026-F1034 (2016-03-11)
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural tetrapeptide with anti-inflammatory and antifibrotic properties. Previously, we have shown that prolyl oligopeptidase (POP) is involved in the Ac-SDKP release from thymosin-β4 (Tβ4). However, POP can only hydrolyze peptides shorter than 30 amino acids, and
Janelisa Musaya et al.
Malawi medical journal : the journal of Medical Association of Malawi, 29(3), 259-264 (2018-06-07)
Anaemia commonly results from destruction of erythrocytes in the peripheral blood and failure of the bone marrow haematopoietic cells to replenish the erythrocytes. The mechanisms involved in trypanosoma-induced anaemia, including the role of the bone marrow haematopoietic cells are incompletely
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