SML2888
LH1306
≥95% (HPLC)
Synonym(s):
2,2’-Dimethyl-3,3’-bis[2-methoxy-3-(2-acetamidoethylamino)-methylpyridin-6-yl-oxymethyl]-1,1’-biphenyl, LH 1306, LH-1306, N,N′-(2,2′-(6,6′-(2,2′-Dimethylbiphenyl-3,3′-diyl)bis(methylene)bis(oxy)bis(2-methoxypyridine-6,3-diyl))bis(methylene)bis(azanediyl)bis(ethane-2,1-diyl))diacetamide
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About This Item
Empirical Formula (Hill Notation):
C38H48N6O6
CAS Number:
Molecular Weight:
684.82
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
shipped in
wet ice
storage temp.
-10 to -25°C
Biochem/physiol Actions
LH1306 is a potent programmed cell death-1/programmed death-ligand 1 (PD-1 (CD279, PDCD1)/PD-L1 (B7-H1, PDCD1-L1)) protein-protein interaction (PPI) inhibitor (IC50 = 25 nM by HTRF assay) that induces symmetrically arranged PD-L1 homodimer formation by targeting PD-L1 at the PD-1 binding site. LH1306 effectively blocks cell surface PD-1/PD-L1 interaction between PD-1-expressing Jurkat cells and co-cultured PD-L1-expressing U2OS cells (SHP-1 recruitment IC50 = 334 nM) or co-cultured PD-L1-expressing aAPC/CHO-K1 cells (NFAT signaling restoration EC50 = 4.21 μM).
Potent programmed cell death-1 (PD-1, CD279, PDCD1)/PD-1 ligand (PD-L1, B7-H1, PDCD1-L1) protein-protein interaction (PPI) inhibitor.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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