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Merck
CN

SML2904

AGF347

≥98% (HPLC)

Synonym(s):

(4-(4-(2-Amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl)-2-fluorobenzoyl)-L-glutamic acid, (S)-2-(4-(4-(2-Amino-4-oxo-3H-pyrrolo[3,2-d]pyrimidin-5(4H)-yl)butyl)-2-fluorobenzamido)pentanedioic acid, N-[4-[4-(2-Amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-L-glutamic acid

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About This Item

Empirical Formula (Hill Notation):
C22H24FN5O6
CAS Number:
2294820-23-6
Molecular Weight:
473.45
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

AGF347, ≥98% (HPLC)

SMILES string

O=C(CC[C@H](NC(C1=CC=C(C=C1F)CCCCN2C=CC(N=C(N3)N)=C2C3=O)=O)C(O)=O)O

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/L, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

AGF347 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) that inhibits mitochondrial C1 metabolism. It also inhibits cytosolic C1 targets such as SHMT1, GARFTase, and AICARFTase. AGF347 inhibits de novo purine biosynthesis. AGF347 exhibits potent broad spectrum in vitro and in vivo antitumor efficacy.
potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2)

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000495144
0000495144
0000121144
0000121145
0000110739

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Aamod S Dekhne et al.
Molecular cancer therapeutics, 18(10), 1787-1799 (2019-07-11)
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT) 2, provides glycine, NAD(P)H, ATP, and C1 units for cytosolic biosynthetic reactions
Aamod S Dekhne et al.
Molecular pharmacology, 97(1), 9-22 (2019-11-11)
Folate-dependent one-carbon (C1) metabolism is compartmentalized in the mitochondria and cytosol and is a source of critical metabolites for proliferating tumors. Mitochondrial C1 metabolism including serine hydroxymethyltransferase 2 (SHMT2) generates glycine for de novo purine nucleotide and glutathione biosynthesis and

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