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Merck
CN

SML2906

Sigma-Aldrich

ERGi-USU

≥98% (HPLC)

Synonym(s):

1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol, 1-[2-Thiazolylazo]-2-naphthol, NSC139021, TAN

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About This Item

Empirical Formula (Hill Notation):
C13H9N3OS
CAS Number:
1147-56-4
Molecular Weight:
255.30
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

faint brown to dark red

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[s]1c(ncc1)N=Nc2c3c(ccc2O)cccc3

InChI

1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H

InChI key

IOMXCGDXEUDZAK-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

ERGi-USU is a selective and potent inhibitor of growth of ERG positive cancer cell lines, while spearing normal prostate or endothelial cells. It potently inhibits growth of ERG positive VCaP xenografts in mice. ERGi-USU is a potent and selective ligand of the ribosomal atypical kinase RIOK2 (right open reading frame (RIO) kinase 2) that induces ribosomal stress.
potent and selective ligand of the ribosomal atypical kinase RIOK2; inhibitor of growth of ERG positive cancer cell lines

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000109776
0000109775
0000104159

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Ahmed A Mohamed et al.
Cancer research, 78(13), 3659-3671 (2018-05-02)
Oncogenic activation of the ETS-related gene (ERG) by recurrent gene fusions (predominantly TMPRSS2-ERG) is one of the most validated and prevalent genomic alterations present in early stages of prostate cancer. In this study, we screened small-molecule libraries for inhibition of

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