SML2906
ERGi-USU
≥98% (HPLC)
Synonym(s):
1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol, 1-[2-Thiazolylazo]-2-naphthol, NSC139021, TAN
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About This Item
Empirical Formula (Hill Notation):
C13H9N3OS
CAS Number:
Molecular Weight:
255.30
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[s]1c(ncc1)N=Nc2c3c(ccc2O)cccc3
InChI
1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H
InChI key
IOMXCGDXEUDZAK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
faint brown to dark red
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
ERGi-USU is a selective and potent inhibitor of growth of ERG positive cancer cell lines, while spearing normal prostate or endothelial cells. It potently inhibits growth of ERG positive VCaP xenografts in mice. ERGi-USU is a potent and selective ligand of the ribosomal atypical kinase RIOK2 (right open reading frame (RIO) kinase 2) that induces ribosomal stress.
potent and selective ligand of the ribosomal atypical kinase RIOK2; inhibitor of growth of ERG positive cancer cell lines
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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Ahmed A Mohamed et al.
Cancer research, 78(13), 3659-3671 (2018-05-02)
Oncogenic activation of the ETS-related gene (ERG) by recurrent gene fusions (predominantly TMPRSS2-ERG) is one of the most validated and prevalent genomic alterations present in early stages of prostate cancer. In this study, we screened small-molecule libraries for inhibition of
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