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Merck
CN

SML2922

Sigma-Aldrich

SEW84

≥98% (HPLC)

Synonym(s):

1-(4-Fluorophenyl)-1H-pyrrole-2-carboxylic acid 2-[thioxo[[3-(trifluoromethylphenyl]-amino]methyl]hydrazide

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About This Item

Empirical Formula (Hill Notation):
C19H14F4N4OS
CAS Number:
259089-67-3
Molecular Weight:
422.40
MDL number:
MFCD01764773
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(ccc1)NC(=S)NNC(=O)c2[n](ccc2)c3ccc(cc3)F

InChI

1S/C19H14F4N4OS/c20-13-6-8-15(9-7-13)27-10-2-5-16(27)17(28)25-26-18(29)24-14-4-1-3-12(11-14)19(21,22)23/h1-11H,(H,25,28)(H2,24,26,29)

InChI key

QEJONNSHVNSZBJ-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

SEW84 is a potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity without inhibition of basal Hsp90 ATPase. It binds to the C-terminal domain of Aha1 and weakens the Hsp90-Aha1 interaction. SEW84 inhibits Aha1-dependent Hsp90 chaperoning activities including refolding of denatured firefly luciferase (in vitro) and in vivo transcriptional activity of the glucocorticoid receptor and AR androgen receptor in prostate cancer cell-based models. SEW84 preferentially clears Alzheimer disease related phosphorylated aggregation-prone Tau in primary rat cortical neurons.
potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000108956
0000108955
0000105559

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Jay K Singh et al.
Cell chemical biology, 27(3), 292-305 (2020-02-06)
Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-Hsp90 inhibitors. Here, we

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