SML2922
SEW84
≥98% (HPLC)
Synonym(s):
1-(4-Fluorophenyl)-1H-pyrrole-2-carboxylic acid 2-[thioxo[[3-(trifluoromethylphenyl]-amino]methyl]hydrazide
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About This Item
Empirical Formula (Hill Notation):
C19H14F4N4OS
CAS Number:
Molecular Weight:
422.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC(F)(F)c1cc(ccc1)NC(=S)NNC(=O)c2[n](ccc2)c3ccc(cc3)F
InChI
1S/C19H14F4N4OS/c20-13-6-8-15(9-7-13)27-10-2-5-16(27)17(28)25-26-18(29)24-14-4-1-3-12(11-14)19(21,22)23/h1-11H,(H,25,28)(H2,24,26,29)
InChI key
QEJONNSHVNSZBJ-UHFFFAOYSA-N
Biochem/physiol Actions
SEW84 is a potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity without inhibition of basal Hsp90 ATPase. It binds to the C-terminal domain of Aha1 and weakens the Hsp90-Aha1 interaction. SEW84 inhibits Aha1-dependent Hsp90 chaperoning activities including refolding of denatured firefly luciferase (in vitro) and in vivo transcriptional activity of the glucocorticoid receptor and AR androgen receptor in prostate cancer cell-based models. SEW84 preferentially clears Alzheimer disease related phosphorylated aggregation-prone Tau in primary rat cortical neurons.
potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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