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SML2924

AZ1729

≥98% (HPLC)

Synonym(s):

AZ 1729, N-[3-(2-carbamimidamido-4-methyl-1,3-thiazol-5-yl)phenyl]-4-fluorobenzamide

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About This Item

Empirical Formula (Hill Notation):
C18H16FN5OS
CAS Number:
2016864-46-1
Molecular Weight:
369.42
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

Fc1ccc(cc1)C(=O)Nc2cc(ccc2)c3[s]c(nc3C)NC(=N)N

InChI

1S/C18H16FN5OS/c1-10-15(26-18(22-10)24-17(20)21)12-3-2-4-14(9-12)23-16(25)11-5-7-13(19)8-6-11/h2-9H,1H3,(H,23,25)(H4,20,21,22,24)

InChI key

HULFYSCAJVTAAR-UHFFFAOYSA-N

Biochem/physiol Actions

AZ1729 is a short chain fatty acid receptor FFA2 (GPR43) regulator that acts as a direct allosteric agonist and as a positive allosteric modulator (PAM). AZ1729 selectively enhances Gi-mediated signaling (Gi-biased ligand), but not at those transduced by Gq/G11 pathway.
FFA2 (GPR43) regulator that acts as a direct allosteric agonist and as a positive allosteric modulator (PAM); Gi-biased ligand

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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