SML2925
MESM
≥98% (HPLC)
Synonym(s):
5′-(2-Hydroxyphenyl)-1-methylspiro[3H-indole-3,2′(3′H)-[1,3,4]thiadiazol]-2(1H)-one, Manganese-Extracting Small Molecule, VU0028386
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About This Item
Empirical Formula (Hill Notation):
C16H13N3O2S
CAS Number:
Molecular Weight:
311.36
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
S1C2(NN=C1c4c(cccc4)O)c3c(cccc3)N(C2=O)C
InChI key
MKCMWNNDSGMHED-UHFFFAOYSA-N
InChI
1S/C16H13N3O2S/c1-19-12-8-4-3-7-11(12)16(15(19)21)18-17-14(22-16)10-6-2-5-9-13(10)20/h2-9,18,20H,1H3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
MESM is a cell penetrant and non-toxic selective manganese ionophore that potently facilitates of manganese export from cells. MESM can be used to rapidly extract and quantify cellular manganese content in a non-lethal and selective MESMER (Manganese-Extracting Small Molecule Estimation Route) assay. MESM does not impacted Fura-2 AM fluorescence.
cell penetrant and non-toxic selective manganese ionophore that potently facilitates of manganese export from cells
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kyle J Horning et al.
The Journal of biological chemistry, 295(12), 3875-3890 (2020-02-13)
Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures. Conducting a screen of small molecules known to alter cellular Mn levels, we report here that one of these chemicals induces rapid
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