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Merck
CN

SML2935

SBI-425

≥98% (HPLC), TNAP inhibitor, powder

Synonym(s):

5-((5-Chloro-2-methoxyphenyl)sulfonamido)nicotinamide, 5-[[(5-Chloro-2-methoxyphenyl)sulfonyl]amino]-3-pyridinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C13H12ClN3O4S
CAS Number:
1451272-71-1
Molecular Weight:
341.77
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD31652984
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

SBI-425, ≥98% (HPLC)

SMILES string

[S](=O)(=O)(Nc2cncc(c2)C(=O)N)c1c(ccc(c1)Cl)OC

InChI

1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18)

InChI key

SBAITEDLNTYIOE-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

SBI-425 is an orally available, potent and selective inhibitor of TNAP (tissue-nonspecific alkaline phosphase).
TNAP inhibitor (tissue-nonspecific alkaline phosphase)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000487741
0000487741
0000427654
0000427654
0000226817

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Anthony B Pinkerton et al.
Bioorganic & medicinal chemistry letters, 28(1), 31-34 (2017-11-28)
Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePPi), a potent mineralization inhibitor, to phosphate (Pi). By the controlled hydrolysis of ePPi, TNAP maintains the correct ratio of
Campbell R Sheen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 824-836 (2014-11-28)
Medial vascular calcification (MVC) is a pathological phenomenon that causes vascular stiffening and can lead to heart failure; it is common to a variety of conditions, including aging, chronic kidney disease, diabetes, obesity, and a variety of rare genetic diseases.
Filippo Romanelli et al.
PloS one, 12(10), e0186426-e0186426 (2017-10-13)
Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity

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