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Merck
CN

SML2947

Penehyclidine hydrochloride

≥98% (HPLC)

Synonym(s):

α-[(1-Azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-benzenemethanol hydrochloride, 3-(2′-phenyl-2′-cyclopentyl-2′-hydroxyl-ethoxy) quinuclidine, Penequine hydrochloride, Penequinine

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About This Item

Empirical Formula (Hill Notation):
C20H29NO2 · HCl
CAS Number:
151937-76-7
Molecular Weight:
351.91
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD11040804

Key Documents

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SMILES string

[Cl-].N21CC(C(CC2)CC1)OCC(O)(C4CCCC4)c3ccccc3.[H+]

InChI

1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H

InChI key

DDTVVMRZNVIVQM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder (hygroscopic)

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Penehyclidine hydrochloride is a brain penetrant anticholinergic drug that exhibits both antimuscarinic and antinicotinic activity. Penehyclidine hydrochloride does not induce muscarinic 2 receptor-associated cardiovascular side effects. Penehyclidine hydrochloride is effective in experimental models of heart, lung and brain ischemia reperfusion injury.
brain penetrant anticholinergic drug that exhibits both antimuscarinic and antinicotinic activity

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000334719
0000334719
0000211065
0000211066
0000211066

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Yaguang Wang et al.
Drug design, development and therapy, 12, 3289-3299 (2018-10-17)
Penehyclidine hydrochloride (PHC) is an anticholinergic drug manufactured in China. It is used widely in clinics as a reversal agent in cases of organic phosphorus poisoning and as a preanesthetic medication. Compared with other anticholinergic agents, PHC confers substantial advantages.
Yong-An Wang et al.
Life sciences, 78(2), 210-223 (2005-09-13)
Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated
Yaguang Wang et al.
European journal of pharmacology, 839, 1-11 (2018-09-12)
Penehyclidine hydrochloride (PHC) is a new anticholinergic agent that provides protective effects in experimental models of heart and brain ischaemia as well as reperfusion (I/R) injury. In this study, we tested the hypothesis that PHC can alleviate lung ischaemia-reperfusion injury

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