SML2948
Mca-APK(Dnp)-OH trifluoroacetate
≥97% (HPLC), ACE2 substrate, film or powder
Synonym(s):
Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt
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About This Item
Empirical Formula (Hill Notation):
C32H36N6O12 · xC2HF3O2
Molecular Weight:
696.66 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
film or powder
Storage condition:
desiccated
Product Name
Mca-APK(Dnp)-OH trifluoroacetate, ≥97% (HPLC)
Quality Segment
assay
≥97% (HPLC)
form
film or powder
storage condition
desiccated
color
white to dark beige
storage temp.
−20°C
Biochem/physiol Actions
Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.
Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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