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Merck
CN

SML2967

Gp91ds-tat, scrambled trifluoroacetate

≥95% (HPLC)

Synonym(s):

Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Leu-Arg-Ile-Thr-Arg-Gln-Ser-Arg-NH2 trifluoroacetate, Gp91 ds-tat, scrambled trifluoroacetate, NADPH oxidase 2 docking sequence-tat trifluoroacetate, NOX2 ds-tat, scrambled trifluoroacetate, NOX2ds-tat, scrambled trifluoroacetate, RKKRRQRRR-CLRITRQSR-NH2 trifluoroacetate, scrambled Gp91phox docking sequence-tat trifluoroacetate, scrambled NOX2 docking sequence-tat trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C98H190N50O22S · xC2HF3O2
Molecular Weight:
2452.94 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200

Key Documents

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assay

≥95% (HPLC)

form

film or powder

color

white to off-white

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Inactive control peptide for the NADPH oxidase inhibitor peptide gp91ds-tat (NOX2ds-tat). The control peptide is composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (aa49-57) N-terminal to a scrambled sequence of murine gp91phox (NOX2) aa86-94.
Scrambled inactive control peptide for the NADPH oxidase inhibitor peptide gp91ds-tat (NOX2ds-tat).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
This item has

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Certificates of Analysis (COA)

Lot/Batch Number
0000167012
0000167012
0000119243
0000108979

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F E Rey et al.
Circulation research, 89(5), 408-414 (2001-09-05)
We previously reported enhanced expression of the p67(phox) and gp91(phox) components of NAD(P)H oxidase in angiotensin (Ang) II-induced hypertension, suggesting de novo assembly in response to Ang II. To examine the direct involvement of NAD(P)H oxidases in Ang II-induced O(2)(-)
Dina Vara et al.
Haematologica, 104(9), 1879-1891 (2019-01-27)
The regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagnetic resonance spectroscopy and turbidimetry
Boris Sabirzhanov et al.
Brain, behavior, and immunity, 80, 73-87 (2019-02-27)
NADPH oxidase (NOX2) is an enzyme that induces reactive oxygen species (ROS) and serves as a switch between the pro-inflammatory and neurorestorative microglial/macrophage phenotypes; such changes play an important role in neuropathic pain and motor dysfunction. Increased NOX2 expression after

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