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SML2980

G6PDi-1

Name: G6PDi-1
Brand: SIGMA

≥98% (HPLC), G6PD inhibitor, powder

Synonym(s):

4-([5-oxo-6H,7H,8H,9H-cyclohepta[d]pyrimidin-2-yl]amino)thiophene-2-carbonitrile

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂N₄OS

CAS Number:

2457232-14-1

Molecular Weight:

284.34

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD32899271

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

G6PDi-1, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N#CC1=CC(NC2=NC=C3C(CCCCC3=N2)=O)=CS1

InChI

1S/C14H12N4OS/c15-6-10-5-9(8-20-10)17-14-16-7-11-12(18-14)3-1-2-4-13(11)19/h5,7-8H,1-4H2,(H,16,17,18)

InChI key

USWCHVCZOGGQQA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

G6PDi-1 is a cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 strongly depletes NADPH in lymphocytes. It decreases inflammatory cytokine response in macrophages, and suppresses respiratory burst in neutrophils.

cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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