SML2980
G6PDi-1
≥98% (HPLC), G6PD inhibitor, powder
Synonym(s):
4-([5-oxo-6H,7H,8H,9H-cyclohepta[d]pyrimidin-2-yl]amino)thiophene-2-carbonitrile
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About This Item
Empirical Formula (Hill Notation):
C14H12N4OS
CAS Number:
Molecular Weight:
284.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
G6PDi-1, ≥98% (HPLC)
InChI
1S/C14H12N4OS/c15-6-10-5-9(8-20-10)17-14-16-7-11-12(18-14)3-1-2-4-13(11)19/h5,7-8H,1-4H2,(H,16,17,18)
InChI key
USWCHVCZOGGQQA-UHFFFAOYSA-N
SMILES string
N#CC1=CC(NC2=NC=C3C(CCCCC3=N2)=O)=CS1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
G6PDi-1 is a cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 strongly depletes NADPH in lymphocytes. It decreases inflammatory cytokine response in macrophages, and suppresses respiratory burst in neutrophils.
cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jonathan M Ghergurovich et al.
Nature chemical biology, 16(7), 731-739 (2020-05-13)
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduced nicotinamide adenine dinucleotide phosphate (NADPH). The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate
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