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SML2981

EN219

≥98% (HPLC)

Synonym(s):

1-(3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone, 3,5-bis(4-Bromophenyl)-1-(chloroacetyl)-4,5-dihydro-1H-pyrazole

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About This Item

Empirical Formula (Hill Notation):
C17H13Br2ClN2O
CAS Number:
380351-29-1
Molecular Weight:
456.56
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02989881
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Brc1ccc(cc1)C2N(NC(=C2)c3ccc(cc3)Br)C(=O)CCl

InChI key

PREWPJFURADJST-UHFFFAOYSA-N

Biochem/physiol Actions

EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.
cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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