SML2986
NSC 15520
≥98% (HPLC)
Synonym(s):
15-Carboxy-13-isopropylatis-13-ene-17,18-dioic acid, NSC15520
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About This Item
Empirical Formula (Hill Notation):
C24H34O6
CAS Number:
Molecular Weight:
418.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[P](=O)(OCC\C(=C(/N(Cc2c(nc(nc2)C)N)C=O)\C)\SC(=O)c1ccccc1)(O)O
InChI
1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+
InChI key
BTNNPSLJPBRMLZ-GHRIWEEISA-N
Biochem/physiol Actions
Inhibitor of the RPA70 N-terminal protein interaction domain
NSC15520 is an inhibitor of the N-terminal protein interaction domain of Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, which is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. It has been shown to block the association of RPA to p53 and RAD9. In pluripotent stem cells, NSC 15520 increased targeted nucleotide substitutions in CRISPER reactions using Cas9n and Cpf1. It has been used along with a group of other small molecules to achieve a 2.8 to 7.2-fold increase in precision gene editing with Cas9.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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