SML2999
KL201
≥97% (HPLC)
Synonym(s):
2-Bromo-N-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-benzamide
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About This Item
Empirical Formula (Hill Notation):
C17H14BrN3OS
CAS Number:
Molecular Weight:
388.28
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C17H14BrN3OS/c18-12-7-3-1-5-10(12)16(22)21-15-14-11-6-2-4-8-13(11)23-17(14)20-9-19-15/h1,3,5,7,9H,2,4,6,8H2,(H,19,20,21,22)
InChI key
KFSLRFWIPVMBNT-UHFFFAOYSA-N
SMILES string
O=C(C1=CC=CC=C1Br)NC2=NC=NC3=C2C4=C(CCCC4)S3
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
KL201 is a circadian clock modulator that lengthens a circadian period in cells and tissues. KL201 selectively regulate cryptochrome 1 (Cry1). It binds to FAD-binding pocket of CRY1 preventing interaction with FBXL3 and ubiquitin-dependent degradation.
circadian clock modulator that lengthens a circadian period; stabilizes cryptochrome 1 (Cry1)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Simon Miller et al.
Cell chemical biology, 27(9), 1192-1198 (2020-06-06)
Cryptochrome 1 (CRY1) and CRY2 are core regulators of the circadian clock, and the development of isoform-selective modulators is important for the elucidation of their redundant and distinct functions. Here, we report the identification and functional characterization of a small-molecule
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