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SML3003

AS3334034

≥98% (HPLC)

Synonym(s):

7-Methoxy-6-(2-methylpropane-2-sulfonyl)-N-(4-methyl-1H-pyrazol-3-yl)quinolin-4-amine

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About This Item

Empirical Formula (Hill Notation):
C18H22N4O3S
CAS Number:
2724942-14-5
Molecular Weight:
374.46
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=CNN=C1NC2=CC=NC3=CC(OC)=C(S(=O)(C(C)(C)C)=O)C=C32

InChI

1S/C18H22N4O3S/c1-11-10-20-22-17(11)21-13-6-7-19-14-9-15(25-5)16(8-12(13)14)26(23,24)18(2,3)4/h6-10H,1-5H3,(H2,19,20,21,22)

InChI key

WCPMUQAUSFXFJE-UHFFFAOYSA-N

Biochem/physiol Actions

AS3334034 is an orally available, potent and selective RIP2 (Receptor-interacting protein kinase 2) inhibitor that exhibits renoprotective effects in uninephrectomized adriamycin-induced CKD (chronic kidney disease) rats. It appears that AS3334034 suppresses the progression of chronic renal failure via an anti-inflammatory effect.
Orally available, potent and selective RIP2 inhibitor that exhibits renoprotective effects

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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