SML3003
AS3334034
≥98% (HPLC)
Synonym(s):
7-Methoxy-6-(2-methylpropane-2-sulfonyl)-N-(4-methyl-1H-pyrazol-3-yl)quinolin-4-amine
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About This Item
Empirical Formula (Hill Notation):
C18H22N4O3S
CAS Number:
Molecular Weight:
374.46
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CC1=CNN=C1NC2=CC=NC3=CC(OC)=C(S(=O)(C(C)(C)C)=O)C=C32
InChI
1S/C18H22N4O3S/c1-11-10-20-22-17(11)21-13-6-7-19-14-9-15(25-5)16(8-12(13)14)26(23,24)18(2,3)4/h6-10H,1-5H3,(H2,19,20,21,22)
InChI key
WCPMUQAUSFXFJE-UHFFFAOYSA-N
Biochem/physiol Actions
AS3334034 is an orally available, potent and selective RIP2 (Receptor-interacting protein kinase 2) inhibitor that exhibits renoprotective effects in uninephrectomized adriamycin-induced CKD (chronic kidney disease) rats. It appears that AS3334034 suppresses the progression of chronic renal failure via an anti-inflammatory effect.
Orally available, potent and selective RIP2 inhibitor that exhibits renoprotective effects
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yusuke Wada et al.
The Journal of pharmacology and experimental therapeutics, 374(3), 428-437 (2020-06-21)
Renal inflammation is a final common pathway of chronic kidney disease (CKD), and its progression can be used to effectively gauge the degree of renal dysfunction. Inflammatory mechanisms contribute to glomerulosclerosis and tubulointerstitial fibrosis, which are hallmarks of CKD leading
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3003-5MG | 04065266864670 |
| SML3003-25MG | 04065266864663 |