SML3006
ICCB-19 Hydrochloride
≥98% (HPLC)
Synonym(s):
N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H21N3OS · HCl
CAS Number:
Molecular Weight:
291.84
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NC1CCCCCC1)CSC2=NCCN2.Cl
InChI key
TZICOTBZKPHMMK-UHFFFAOYSA-N
Biochem/physiol Actions
ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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