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SML3010

Belinostat

≥98% (HPLC)

Synonym(s):

(2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide, (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide, (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide, PX 105684, PX-105684, PX105684, PXD 101, PXD-101, PXD101

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O4S
CAS Number:
866323-14-0
Molecular Weight:
318.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD08064035
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(Nc2ccccc2)c1cc(ccc1)\C=C\C(=O)NO

InChI

1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChI key

NCNRHFGMJRPRSK-MDZDMXLPSA-N

Biochem/physiol Actions

Potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor with anti-cancer efficacy in vitro and in vivo.
Belinostat (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 1B - Repr. 2 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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