SML3016
Afobazole
≥98% (HPLC)
Synonym(s):
2-((2-Morpholino)ethylthio)-5-ethoxybenzimidazole, 5-Ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, 6-Ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, Afobazol, Aphobazole, CM 346, Fabomotizole
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About This Item
Empirical Formula (Hill Notation):
C15H21N3O2S
CAS Number:
Molecular Weight:
307.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
film
color
white to beige
storage temp.
2-8°C
SMILES string
CCOC1=CC2=C(C=C1)N=C(SCCN3CCOCC3)N2
InChI
1S/C15H21N3O2S/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18/h3-4,11H,2,5-10H2,1H3,(H,16,17)
InChI key
WWNUCVSRRUDYPP-UHFFFAOYSA-N
Biochem/physiol Actions
Afobazole is an anxiolytic that appears to act via σ-1 and σ2 receptors. Afobazole exhibit neuroprotective potential in both in vivo and in vitro models. It is a potent modulator of microglia.
anxiolytic that appears to act via σ-1 and σ-2 receptors
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
wgk
WGK 3
Regulatory Information
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Mikhail V Voronin et al.
Pharmacology research & perspectives, 4(6), e00273-e00273 (2017-01-18)
Anxiolytic afobazole (5-Ethoxy-2-[2-(morpholino)-ethylthio]benzimidazole dihidrochloride) has pronounced ligand properties toward Sigma-1 receptor (σ1 receptor,SigmaR1) and MT 3 receptors. Our previous work demonstrated that afobazole possess cytoprotective effect in the in vitro model of menadione genotoxicity (Woods et al. 1997) through interaction with MT
Javier Cuevas et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 161-172 (2011-07-01)
Microglial cells play a critical role in the neuroinflammatory response that accompanies various diseases of the central nervous system, such as ischemic stroke, and ATP is a major signaling molecule regulating the response of these cells to these pathophysiological conditions.
Javier Cuevas et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 152-160 (2011-07-01)
Afobazole is an anxiolytic medication that has been previously shown to be neuroprotective both in vitro and in vivo. However, the mechanism(s) by which afobazole can enhance neuronal survival remain poorly understood. Experiments were carried out to determine whether afobazole
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3016-5MG | 04065265932899 |
| SML3016-25MG | 04065265932882 |