SML3021
ADLumin-1
≥98% (HPLC)
Synonym(s):
6-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one, 6-[4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-2-methyl-imidazo[1,2-a]pyrazin-3(7H)-one
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About This Item
Empirical Formula (Hill Notation):
C19H20N4O
CAS Number:
Molecular Weight:
320.39
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
CN(C1=CC=C(C=C1)/C=C/C=C/C2=CN3C(N=C(C3=O)C)=CN2)C
assay
≥98% (HPLC)
form
powder
color
faint yellow to dark orange
solubility
H2O: 0.1 mg/mL (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
ADLumin-1 brain blood barrier penetrant smart chemiluminescence probe for Aβ (amyloid beta) species. Upon binding to Aβ, ADLumin-1 chemiluminescence dramatically increases and its peak shifts from 590 nm to 540 nm. ADLumin-1 is suitable for in vivo dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) with CRANAD-3 a smart NIRF (near infrared fluorescence imaging) probe for Aβs. Apparently both probes bind to Aβ aggregates in close proximity.
brain blood barrier penetrant smart chemiluminescence probe for Aβ (amyloid beta) species
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jing Yang et al.
Nature communications, 11(1), 4052-4052 (2020-08-15)
Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates
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