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SML3050

Olsalazine sodium

Name: Olsalazine sodium
Brand: SIGMA

Synonym(s):

Olsalazine sodium, 3,3´-Azobis(6-hydroxybenzoic acid) sodium, 5,5′-Azodisalicylic acid sodium, 5,5′-azobis(salicylic acid) sodium, C.I. Mordant Yellow 5; 3,3′-dicarboxy-4,4′-dihydroxyazobenzene sodium, azodisal sodium

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₈N₂O₆ · 2Na

CAS Number:

6054-98-4

Molecular Weight:

346.20

UNSPSC Code:

12352200

NACRES:

NA.24

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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assay

≥98% (HPLC)

Quality Level

100

form

powder

color

white to beige

solubility

H₂O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Na+].[Na+].N(=N\c2cc(c(cc2)[O-])C(=O)O)/c1cc(c(cc1)[O-])C(=O)O

InChI

1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-15+;;

InChI key

ZJEFYLVGGFISGT-VRZXRVJBSA-L

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Biochem/physiol Actions

Olsalazine is an anti-inflammatory drug used in inflammatory bowel disease and ulcerative colitis treatments. It is a pro-drug of 5-aminosalicylic acid (mesalamine) that it is converted by the bacteria in the colon to mesalamine. Olsalazine (5-aminosalicylic acid) is consider as a broad-spectrum anticancer agent. Additionally, olsalazine increases both eEF1A2 and utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Anticancer Activity of Water-Soluble Olsalazine-PAMAM-Dendrimer-Salicylic Acid-Conjugates.

Sandra Cortez-Maya et al.

Biomolecules, 9(8) (2019-08-16)

Improving the activity and selectivity profile of anticancer agents will require designing drug carrier systems that employ soluble macromolecules. Olsalazine-PAMAM-dendrimer-salicylic acid-conjugates with dendritic arms of different lengths have shown good stability regarding the chemical link between drug and spacer. In

An experimental study on ulcerative colitis as a potential target for probiotic therapy by Lactobacillus acidophilus with or without "olsalazine".

Amany A Abdin et al.

Journal of Crohn's & colitis, 2(4), 296-303 (2008-12-01)

Traditional medical treatments for ulcerative colitis (UC) are still compromised by its adverse effects and not potent enough to keep in remission for long-term periods. So, new therapies that are targeted at specific disease mechanisms have the potential to provide

Global Trade Item Number

SKU	GTIN
SML3050-10MG	04065266056792
SML3050-50MG	04065266056808

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