SML3062
BSJ-04-122-R
≥98% (HPLC)
Synonym(s):
N-(2-((5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)phenyl)propionamide
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About This Item
Empirical Formula (Hill Notation):
C15H14ClN5O
CAS Number:
Molecular Weight:
315.76
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CNC2=NC=NC(NC3=CC=CC=C3NC(CC)=O)=C21
InChI
1S/C15H14ClN5O/c1-2-12(22)20-10-5-3-4-6-11(10)21-15-13-9(16)7-17-14(13)18-8-19-15/h3-8H,2H2,1H3,(H,20,22)(H2,17,18,19,21)
InChI key
XWBFUHLMYSMDTN-UHFFFAOYSA-N
Biochem/physiol Actions
BSJ-04-122-R is a reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122. BSJ-04-122-R des not inhibit JNK phosphorylation.
reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Jie Jiang et al.
Cell chemical biology, 27(12), 1553-1560 (2020-09-12)
MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them a potential target for inhibitor
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