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Merck
CN

SML3095

SGC-BRDVIII-NC

≥98% (HPLC)

Synonym(s):

1,1-Dimethylethyl 4-[3-amino-6-(2-methoxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate, SGC-SMARCA-BRDVIII inactive control, SGC-SMARCA-BRDVIII negative control, tert-Butyl 4-[3-amino-6-(2-methoxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C20H27N5O3
CAS Number:
2650530-02-0
Molecular Weight:
385.46
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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InChI

1S/C20H27N5O3/c1-20(2,3)28-19(26)25-11-9-24(10-12-25)16-13-15(22-23-18(16)21)14-7-5-6-8-17(14)27-4/h5-8,13H,9-12H2,1-4H3,(H2,21,23)

InChI key

YOBVMDSDYHOOLN-UHFFFAOYSA-N

SMILES string

O=C(N1CCN(CC1)C2=C(N)N=NC(C3=CC=CC=C3OC)=C2)OC(C)(C)C

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Inactive analog of and the negative control for the SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor SGC-SMARCA-BRDVIII.
SGC-BRDVIII-NC is an inactive analog of and the recommended negative control for the potent, SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain (BRD) inhibitor SGC-SMARCA-BRDVIII.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000128885
0000128884
0000126810

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Marek Wanior et al.
Journal of medicinal chemistry, 63(23), 14680-14699 (2020-11-21)
Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails by the bromodomain-containing proteins SMARCA2 (BRM), SMARCA4 (BRG1), and polybromo-1.

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