SML3098
C-178
≥98% (HPLC)
Synonym(s):
C 178, C178, N-(Dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide, N-3-Dibenzofuranyl-5-nitro-2-furancarboxamide, N-Dibenzofuran-3-yl-5-nitrofuran-2-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C17H10N2O5
CAS Number:
Molecular Weight:
322.27
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
faint yellow to dark brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC(OC3=C4C=CC=C3)=C4C=C2
InChI key
URUVDCCYSJEGQQ-UHFFFAOYSA-N
Biochem/physiol Actions
C-178 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-178 inhibits mSTING-mediated IFNβ reporter activity (IC50 <500 nM) without affecting RIG-I, and blocks (0.5 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells.
Potent and selective, Cys91-targeting covalent inhibitor against murine, but not human, STING.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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