SML3111
ETP-47799
≥98% (HPLC)
Synonym(s):
CDK8/19i-47799, CDK8/19i-CNIO-47799, ETP 47799, ETP47799, Lck-IN-1, N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
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About This Item
Empirical Formula (Hill Notation):
C14H15N5
CAS Number:
Molecular Weight:
253.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3
InChI key
XTMROGQLIVGYKF-UHFFFAOYSA-N
Biochem/physiol Actions
ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD0325901, 1.5μM CHIR 99021).
Potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor that induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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