Skip to Content

Key Documents

View All Documentation

SML3117

N-Desethyl sunitinib hydrochloride

≥98% (HPLC)

Synonym(s):

5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)amide hydrochloride, N-Desethylsunitinib hydrochloride, N-[2-(Ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide hydrochloride, SU 12662 hydrochloride, SU12662 hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C20H23FN4O2 · xHCl
CAS Number:
356068-97-8
Molecular Weight:
370.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD18252482
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Fc1cc2c(cc1)NC(=O)\C\2=C/c3[nH]c(c(c3C)C(=O)NCCNCC)C

InChI

1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-

InChI key

LIZNIAKSBJKPQC-GDNBJRDFSA-N

Biochem/physiol Actions

Multi-target tyrosine kinase inhibitor (TKI); major and pharmacologically active metabolite of an anticancer drug sunitinib;
N-Desethyl sunitinib is a multi-target tyrosine kinase inhibitor that is a major active metabolite of an anticancer drug sunitinib. N-Desethyl sunitinib has a similar kinase inhibitory effect as sunitinib. In patients, plasma sunitinib and N-desethyl sunitinib accounts for 42% and 24%, respectively. Thus N-desethyl sunitinib accounts for one third of the therapeutic effect of oral sunitinib.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2

target_organs

blood vessel,Bone marrow

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library