SML3118
Obatoclax mesylate
≥98% (HPLC)
Synonym(s):
2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole, methanesulfonate salt, GX15-070 mesylate
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About This Item
Empirical Formula (Hill Notation):
C20H19N3O · CH4O3S
CAS Number:
Molecular Weight:
413.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
dark green to black
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC
InChI
1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-;
InChI key
ZFKXDVMHNXPEIY-PEZBNFGJSA-N
Biochem/physiol Actions
BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins with anti-cancer efficacy in vitro and in vivo.
Obatoclax (GX15–070) is a BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins, including A1/Bfl-1, Bcl-2, Bcl-B, Bcl-w, Bcl-XL, and MCL-1. Obatoclax induces cancer cell apoptosis in cultures (0.05-2 μM) and in vivo (1.25-10 mg/kg via im. ip. or iv. in mice) by overcoming Bcl-2 members-mediated resistance to BAX- or BAK-dependent apoptosis.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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