SML3123
NButGT
≥98% (HPLC)
Synonym(s):
(3aR,5R,6S,7R,7aR)-3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-propyl-5H-pyrano[3,2-d]thiazole-6,7-diol
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About This Item
Empirical Formula (Hill Notation):
C10H17NO4S
CAS Number:
Molecular Weight:
247.31
UNSPSC Code:
41106609
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
CCCC1=N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)CO)O)O
Biochem/physiol Actions
NButGT is a potent and selective inhibitor of O-GlcNAcase (OGA), which elevates O-GlcNAc levels but does not cause insulin resistance in 3T3-L1 adipocytes, and in rats and mice. NButGT does not perturbed glucohomeostasis when used for extended time in rats and mice. NButGT attenuates the accumulation of Aβ, neuroinflammation, and memory in in a mouse model of Alzheimer’s disease. NButGT efficiently increased total O-GlcNAc, improves cardiovascular function and reduced animal mortality in rat model of sepsis.
Specific and potent inhibitor of O-GlcNAcase (OGA)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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