SML3124
Gemcabene
≥98% (HPLC)
Synonym(s):
6,6′-Oxybis(2,2-dimethylhexanoic acid), CI-1027, PD72953
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About This Item
Empirical Formula (Hill Notation):
C16H30O5
CAS Number:
Molecular Weight:
302.41
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(O)C(CCCCOCCCCC(C(O)=O)(C)C)(C)C
InChI
1S/C16H30O5/c1-15(2,13(17)18)9-5-7-11-21-12-8-6-10-16(3,4)14(19)20/h5-12H2,1-4H3,(H,17,18)(H,19,20)
InChI key
SDMBRCRVFFHJKR-UHFFFAOYSA-N
Biochem/physiol Actions
Gemcabene is an orally available lipid-regulating compound that induces both a cholesterol and triglyceride reduction by a mechanism of action not linked to agonist or antagonist activity on the PPAR-α receptors. Gemcabene down-regulates apoC-III expression. Gemcabene is primarily metabolized (glucuronidation) by UDP-glucuronosyltransferase2B7 (UGT2B7). Thus, is often used as a UGT2B7 substrate.
orally available lipid-regulating compound that induces both a cholesterol and triglyceride reduction
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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