SML3149
BI8626
≥98% (HPLC)
Synonym(s):
BI 8626, BI-8626, N-(3-(Aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine, N1-[8-[4-(Phenylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidin-4-yl]-1,3-benzenedimethanamine
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About This Item
Empirical Formula (Hill Notation):
C25H28N8
CAS Number:
Molecular Weight:
440.54
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Biochem/physiol Actions
BI8626 is a selective HUWE1 (HECTH9; MULE; ARF-BP1) inhibitor (IC50 = 0.9 µM by HUWE1 HECT-domain auto-ubiquitination assay; IC50 >50 µM against other HECT-domain Ub ligases tested). BI8626 inhibits the degradation of HUWE1 target proteiins, including MCL1, MIZ1, and TopBP1 (10-20 µM). BI8626 suppresses Ls174T colony formation (IC50 = 0.7 µM in 5 days) and the growth of three colon carcinoma cell lines (20 µM for 5 days; HCT116, HT29, SW480).
Selective HUWE1 (HECTH9; MULE; ARF-BP1) inhibitor against HUWE1-mediated degration of target proteins.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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E K Es'kov
Biofizika, 20(4), 646-651 (1975-07-01)
Bee phonoreceptors are revealed by electrophysiological method. These are hair sensillae located between facet eyes and occipital commissure. The region of the highest sensitivity of receptors in within the range of the maximum energy of various sound signals used in
Stefanie Peter et al.
EMBO molecular medicine, 6(12), 1525-1541 (2014-09-26)
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF-BP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required
Aswini Krishnan et al.
Nature communications, 11(1), 2056-2056 (2020-04-30)
Papillary thyroid cancer (PTC) is the most common type of endocrine malignancy. By RNA-seq analysis, we identify a RET rearrangement in the tumour material of a patient who does not harbour any known RAS or BRAF mutations. This new gene
Theresa Endres et al.
Molecular cell, 81(4), 830-844 (2021-01-17)
The MYC oncoprotein globally affects the function of RNA polymerase II (RNAPII). The ability of MYC to promote transcription elongation depends on its ubiquitylation. Here, we show that MYC and PAF1c (polymerase II-associated factor 1 complex) interact directly and mutually
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