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SML3169

NR162

≥98% (HPLC)

Synonym(s):

4-(Cyclopentylamino)-2-(2,5-dibromo-4-methylbenzylamino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C24H30Br2N6O3
Molecular Weight:
610.34
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

NR162 is a potent and selective (per DiscoverX KINOMEScan) inhibitor against the calcium/calmodulin-dependent serine protein kinase CASK (Kd = 22 nM by ITC; IC50 = 80 nM by NanoBRET) with much reduced or little potency against other kinases tested (IC50 = 3.8 μM/TYRO3, 18.2 μM/ERBB3, >20 μM/ABL1, AURKC, RPS6KA6, PIKFYVE, RPS6KA5, LRRK2, STK38L by NanoBRET).
Potent and selective inhibitor against the calcium/calmodulin-dependent serine protein kinase CASK.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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