SML3170
QPD-Otf
≥98% (HPLC)
Synonym(s):
4-chloro-2-(6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl trifluoromethanesulfonate
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About This Item
Empirical Formula (Hill Notation):
C15H7Cl2F3N2O4S
CAS Number:
Molecular Weight:
439.19
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C1NC(C2=C(C=CC(Cl)=C2)OS(=O)(C(F)(F)F)=O)=NC3=CC=C(C=C31)Cl
Biochem/physiol Actions
QPD-OTf is a cell penetrant activity-based fluorogenic substrate for kinesin-1 that apparently binds to the nucleotide-binding site which removes triflate caging causing precipitation and crystallization of fluorescent QPD along microtubule cytoskeleton marking a kinesin-1 path from Golgi apparatus toward the cell periphery. QPD-OTf is not a substrate for Eg5.
cell penetrant activity-based fluorogenic substrate for kinesin-1
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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