SML3184
Santacruzamate A
≥98% (HPLC)
Synonym(s):
CAY 10683, CAY-10683, CAY10683, N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]carbamic acid ethyl ester
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About This Item
Empirical Formula (Hill Notation):
C15H22N2O3
CAS Number:
Molecular Weight:
278.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
SMILES string
O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1
InChI key
HTOYBIILVCHURC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = > 1 μM and 433.5 nM, respectively). CAY10683 readily enhances cellular acetylated HDAC2 levels upon LPS-stimulation and only modestly inhibits HuT-78 cutaneous T-cell lymphoma and HCT-116 colon carcinoma cells growth (GI50 = 1.4 and 29.4 uM, respectively). It alleviates acute liver failure (ALF) in rats (i.p.) and rescues cognitive deficits in APPswe/PS1dE9 mice (p.o.).
cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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