SML3189
BMS-265246
≥98% (HPLC)
Synonym(s):
(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone, BMS 265246, BMS265246
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About This Item
Empirical Formula (Hill Notation):
C18H17F2N3O2
CAS Number:
Molecular Weight:
345.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)
SMILES string
FC1=C(C(F)=CC(C)=C1)C(C2=C(C3=C(N=C2)NN=C3)OCCCC)=O
InChI key
SCFMWQIQBVZOQR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
BMS-265246 is an ATP site-targeting, potent and CDK1/2-selective cyclin-dependent kinase inhibitor (IC50 = 6 nM/CDK1, 9 nM/CDK2, 230 nM/CDK4) with anti-cancer efficacy in A2780 ovarian cancer culture (IC50 = 760 nM).
ATP site-targeting, potent and CDK1/CDK2-selective cyclin-dependent kinase inhibitor with anti-cancer efficacy in A2780 ovarian cancer culture.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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