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SML3191

Cotrimoxazole

Name: Cotrimoxazole
Brand: SIGMA

≥98% (HPLC), Antibiotic, powder

Synonym(s):

4-Amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine, TMP/SMX, Trimethoprim/sulfamethoxazole

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₈N₄O₃·5C₁₀H₁₁N₃O₃S

CAS Number:

8064-90-2

Molecular Weight:

1556.71

UNSPSC Code:

12352107

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Cotrimoxazole, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChI key

WZRJTRPJURQBRM-UHFFFAOYSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Cotrimoxazole is a combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole that is used to treat a variety of bacterial infections both Gram-positive and Gram-negative. Sulfamethoxazole inhibits bacterial dihydropteroate synthase while trimethoprim inhibits bacterial dihydrofolate reductase, thereby blocking the synthesis of nucleic acids.

combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361d

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Safety of cotrimoxazole in pregnancy: a systematic review and meta-analysis.

Nathan Ford et al.

Journal of acquired immune deficiency syndromes (1999), 66(5), 512-521 (2014-05-24)

Cotrimoxazole is widely prescribed to treat a range of infections, and for HIV-infected individuals it is administered as prophylaxis to protect against opportunistic infections. Some reports suggest that fetuses exposed to cotrimoxazole during early pregnancy may have an increased risk

Global Trade Item Number

SKU	GTIN
SML3191-25MG	04065267317489
SML3191-5MG	04065267317496

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