SML3192
GLX481304
≥98% (HPLC)
Synonym(s):
2-N-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1,3,5-triazine-2,4-diamine, N-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine, N2-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine, [4-Amino-6-[4-(3-methoxy-phenyl)-piperazin-1-ylmethyl]-1H-[1,3,5]triazin-2-ylidene]-(3,4-dimethyl-phenyl)-amine
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About This Item
Empirical Formula (Hill Notation):
C23H29N7O
CAS Number:
Molecular Weight:
419.52
NACRES:
NA.77
UNSPSC Code:
12352107
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
GLX481304 is a cell-permeable, noncytotoxic triazine-diamino compound that acts a potent, dual NOX2 and NOX4 isoform-selective inhibitor (IC50 ~ 1.25 μM) over NOX1. Does neither function as an antioxidant nor as a scavenger of reactive oxygen species (ROS). GLX481304 is shown to dose-dependently reduce ROS levels in hypoxia challenged mouse cardiomyocytes and improve contractile function in whole heart.
cell-permeable, noncytotoxic triazine-diamino compound that acts a potent, dual NOX2 and NOX4 isoform-selective inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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