SML3204
Dapansutrile
≥98% (HPLC)
Synonym(s):
3-(Methylsulfonyl)propanenitrile; 3-(Methylsulfonyl)propionitrile, Dapansutrile
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About This Item
Empirical Formula (Hill Notation):
C4H7NO2S
CAS Number:
Molecular Weight:
133.17
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
LQFRYKBDZNPJSW-UHFFFAOYSA-N
SMILES string
O=S(C)(CCC#N)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Dapansutrile is an orally active, specific and potent inhibitor of NLRP3 inflammasome activation that decreases IL-1β and IL-18 release. Dapansutrile exhibits no effect on NLRC4 and AIM2 inflammasomes activation. It appears that Dapansutrile directly interact with NLRP3. It does not show hematological, or organ toxicities in humans at oral doses up to 1,000 mg/day
orally active, specific and potent inhibitor of NLRP3 inflammasome activation; anti-inflammatory
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
Arthritis Research & Therapy, 20(1), 169-169 (2018)
OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
Proceedings of the National Academy of Sciences of the USA, 115(7), E1530-E1539 (2018)
The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
Journal of Cardiovascular Pharmacology, 73(4), 215-222 (2019)
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